Current bone tumour projects

Malignant bone tumours are diagnosed in around 60 children every year in the UK. The survival rate is among the lowest of all the childhood cancers.

There are two main types of bone tumour diagnosed in childhood – osteosarcoma and Ewing sarcoma.

Read more: Osteosarcoma | Ewing sarcoma

More research is urgently needed to improve our understanding of childhood bone tumours and improve the outlook for young patients. Our current projects are listed below.

Developing immunotherapy for childhood sarcomas

Isabelle Gore 14 September 2015
Professor John Anderson, UCL Institute of Child Health, London

Immunotherapy is emerging as an important new line of defence against childhood cancers that do not respond to chemotherapy. Success has already been achieved in the treatment of children with leukaemia and neuroblastoma using immunotherapy techniques. Professor Anderson and colleagues now aim to extend these techniques to the treatment of childhood sarcomas. 

Amount of grant: £181,213 | Date of award: May 2015 Overview One of the greatest challenges facing paediatric oncologists is the management of children with tumours that are resistant to chemotherapy, especially when the...
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A novel combination therapy to treat metastatic Ewing sarcoma

Isabelle Gore 01 March 2013
Dr Ariadna Mendoza, UCL Cancer Institute

When Ewing sarcoma, a tumour of the bone, spreads to other parts of the body, it is difficult to treat and usually fatal. This project builds on previous work that has identified a promising new approach to treatment, combining two different types of drugs.

If successful, the team will take the new therapy forward to clinical trial.

Amount of grant: £243,559  |  Date of award: March 2013 Overview Ewing sarcoma (ES) is the second most common bone tumour in children and adolescents. One third of patients do not survive five years from diagnosis. Most of the deaths are due to metastatic disease – i...
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Assessment of physical function in survivors of childhood bone and soft tissue tumours

Isabelle Gore 01 December 2012
Mr Craig Gerrand, Freeman Hospital, Newcastle upon Tyne

The treatment for bone and soft tissue tumours leaves many children disabled to some degree. We need to understand how these children manage after treatment in order that families get the necessary support to help their child return to ‘normal’ life. The team in Newcastle is working on two devices that can be used to measure children’s physical activity and function. Our funding will enable them to pilot the use of these devices in survivors of these childhood tumours.  

Amount of grant: £47,614  |  Date of award: December 2012 Overview It is important to understand how children and ...
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