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Currently funded treatment projects

All research projects that we fund are first scrutinised by our Scientific Advisory Panel as well as a number of external peer reviewers.

We need to make sure that all projects are of the highest scientific quality and that they represent the best hope of progress in our fight against childhood leukaemia and other cancers.

Once funded, the research teams must provide annual reports to keep us updated with their progress.

Dr Darren Hargrave, Great Ormond Street Hospital

Larry McCarthy 01 October 2011
Targeted therapies for childhood cancer.

Award amount:   £198,011

Date of award:    July 2011

Dr Darren Hargrave and Professor Kathy Pritchard-Jones, Great Ormond Street Hospital for Children

We are helping the team at Great Ormond Street Hospital to take new treatments from the laboratory to the hospital ward.


Overview

Modern treatments enable doctors to cure more than three quarters of children diagnosed with cancer. Despite this, cancer remains one of the main causes of death in children. Most of these deaths result from a group of ... Read More

Professor Tessa Holyoake, University of Glasgow

Isabelle Gore 27 September 2011
We have provided funding to support a new senior research post at the Paul O’Gorman Leukaemia Research Centre in Glasgow.

Amount of grant: £323,603

Date of award: May 2011
 

Background

We helped to fund the cost of building and equipping the new Paul O’Gorman Leukaemia Research Centre in Glasgow, which opened in 2008.

The new Centre forms part of Glasgow’s Institute of Cancer Sciences (ICS), providing a highly interactive research environment where basic scientists and clinical academics benefit from close interactions with the Beatson I... Read More

Professor Tariq Enver, UCL Cancer Institute, London

Liz Daley 01 September 2010

The biology of normal and leukaemic stem and progenitor cells

Amount of grant: £330,000

Date of award: September 2010

Professor Tariq Enver, University College London Cancer Institute

Professor Enver is an international leader in the field of leukaemic stem cells.

His recent breakthrough research has identified the cells in which the most common form of childhood leukaemia first arises.

Stem cells and blood production

Our bone marrow produces millions of blood cells every day.

Three types of cell are produced – red blood cells, wh... Read More

Dr Anjali Shah, University of Oxford

John Smithies 01 December 2009
The impact of predictors of co-morbidity and treatment intensity on survival from leukaemia and other childhood cancers in England and Wales

Amount of grant: £51,905
Date of award: December 2009

Dr Anjali Shah, Dr Michael Murphy and Dr Charles Stiller, Childhood Cancer Research Group, University of Oxford





Background

Survival from leukaemia and other childhood cancers has increased dramatically since the 1970s.

This is thanks to the use of intensive therapy, which has been continuously developed and improved through an ongoing series... Read More
Related Topics Oxford, Dr Anjali Shah

Dr Nicholas Goulden and Dr Chris Mitchell

John Smithies 01 December 2009
New UK childhood ALL trial: UK ALL 2011

Amount of grant: £750,000

Date of award: December 2009


Dr Nicholas Goulden, Great Ormond Street Hospital, London
Dr Chris Mitchell, John Radcliffe Hospital, Oxford

The latest national clinical trial for children with acute lymphoblastic leukaemia started in April 2011.

This replaces the previous trial, UK ALL 2003, which has revolutionised the way that children with acute lymphoblastic leukaemia (ALL) are treated.

Background – clinical trials and leukaemia treatment

Clinical trials help us to fin... Read More

Dr J Anderson and Dr M Pule, Institute for Child Health

John Smithies 08 December 2008
Assessment of anti-PAX5 immunotherapy for paediatric haematological and solid cancers

Amount of grant: £200,289

Date of award: December 2008


Dr John Anderson and Dr Martin Pule, Institute for Child Health, London



This ground-breaking research aims to help children who are failed by existing treatments.

Background

Most children with leukaemia are initially treated with high doses of chemotherapy – to kill the deadly leukaemia cells and enable blood cells to restore their vital functions.

Some children respond well to chemotherapy and n... Read More

Professor P Amrolia and Dr N Goulden, Institute of Child Health

John Smithies 01 December 2008
Immunotherapy after stem cell transplant in children with high-risk acute lymphoblastic leukaemia.

Amount of grant: £348,658

Date of award: December 2008

Professor Persis Amrolia and Dr Nicholas Goulden, Institute of Child Health, London


This ground-breaking research aims to help children who are failed by existing treatments.

Background

When a child is first diagnosed with leukaemia, doctors immediately start an aggressive chemotherapy regime to try to kill the leukaemia cells.

For some children this is enough. But others do not resp... Read More

Professor Persis Amrolia, Institute of Child Health, London

John Smithies 01 December 2008
Improving immune response following bone marrow transplant for children with acute myeloid leukaemia (ALL).

Amount of grant: £348,791

Date of award: December 2008

Background

When a child is diagnosed with acute myeloid leukaemia (AML), doctors immediately start aggressive chemotherapy to kill the deadly leukaemic cells.

Unfortunately this isn’t enough to cure all children; some simply don’t respond to the chemotherapy, others may respond well initially only to relapse. The only hope for these children is a bone marrow transplant.

The chil... Read More

Dr Waseem Qasim, Institute of Child Health, London

John Smithies 01 December 2008
T-cell receptor therapy against leukaemia

Amount of grant: £210,301

Date of award: December 2008

This ground-breaking research aims to help children who are failed by existing treatments.

Dr Qasim and colleagues from both Great Ormond Street Hospital and the Royal Free Hospital in London are collaborating to develop a new technique for treating children who cannot be helped by current treatments.

In essence, they are developing a technique which they hope can be used to boost a child’s own immune response against leukaemia.

Background

A ... Read More

Professor Chris Boshoff, UCL Cancer Institute

John Smithies 01 December 2007
These three different strands of work promise important progress in treating childhood cancer.

Amount of grant: £1,006,808

Date of award: December 2007

Professor Chris Boshoff, Professor Poul Sorensen and Dr Pablo Rodriguez-Viciana
University College London Cancer Institute

The Cancer Institute at University College London opened in September 2007, housed in the spectacular new Paul O’Gorman Building.

We contributed £2 million to the cost of the state-of-the-art research facilities, the eighth research centre to carry Paul’s name.

To hel... Read More
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Registered Charity Number: 298405
Inaugurated by Diana, Princess of Wales

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