Fighting childhood cancer. The greatest reason to give

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Currently funded research projects

CHILDREN with CANCER is the leading national charity dedicated to the fight against childhood leukaemia and other childhood cancer.  We fund life-saving research into the causes, prevention and treatment of childhood cancer.

You can read about all the innovative research projects that we are currently funding below.

Dr Darren Hargrave, Great Ormond Street Hospital

Larry McCarthy 01 October 2011
Targeted therapies for childhood cancer.

Award amount:   £198,011

Date of award:    July 2011

Dr Darren Hargrave and Professor Kathy Pritchard-Jones, Great Ormond Street Hospital for Children

We are helping the team at Great Ormond Street Hospital to take new treatments from the laboratory to the hospital ward.


Overview

Modern treatments enable doctors to cure more than three quarters of children diagnosed with cancer. Despite this, cancer remains one of the main causes of death in children. Most of these deaths result from a group of ... Read More

Professor Tessa Holyoake, University of Glasgow

Isabelle Gore 27 September 2011
We have provided funding to support a new senior research post at the Paul O’Gorman Leukaemia Research Centre in Glasgow.

Amount of grant: £323,603

Date of award: May 2011
 

Background

We helped to fund the cost of building and equipping the new Paul O’Gorman Leukaemia Research Centre in Glasgow, which opened in 2008.

The new Centre forms part of Glasgow’s Institute of Cancer Sciences (ICS), providing a highly interactive research environment where basic scientists and clinical academics benefit from close interactions with the Beatson I... Read More

Dr Mike Murphy & Dr Gerald Draper, University of Oxford

Larry McCarthy 01 January 2011
Studies of retinoblastoma

Amount of grant: £168,039

Date of award: January 2011


Dr Mike Murphy & Dr Gerald Draper
Childhood Cancer Research Group, Oxford

Retinoblastoma is a cancer that affects the lining of the eye (the retina). It is very rare, affecting around 40 children a year in Britain. Almost all patients with retinoblastoma can now be successfully treated, but unfortunately many children with retinoblastoma have a greatly increased risk of developing subsequent cancers.

The research team wants to better understand the reasons f... Read More

Professor Tariq Enver, UCL Cancer Institute, London

Liz Daley 01 September 2010

The biology of normal and leukaemic stem and progenitor cells

Amount of grant: £330,000

Date of award: September 2010

Professor Tariq Enver, University College London Cancer Institute

Professor Enver is an international leader in the field of leukaemic stem cells.

His recent breakthrough research has identified the cells in which the most common form of childhood leukaemia first arises.

Stem cells and blood production

Our bone marrow produces millions of blood cells every day.

Three types of cell are produced – red blood cells, wh... Read More

Dr Anjali Shah, University of Oxford

John Smithies 01 December 2009
The impact of predictors of co-morbidity and treatment intensity on survival from leukaemia and other childhood cancers in England and Wales

Amount of grant: £51,905
Date of award: December 2009

Dr Anjali Shah, Dr Michael Murphy and Dr Charles Stiller, Childhood Cancer Research Group, University of Oxford





Background

Survival from leukaemia and other childhood cancers has increased dramatically since the 1970s.

This is thanks to the use of intensive therapy, which has been continuously developed and improved through an ongoing series... Read More
Related Topics Oxford, Dr Anjali Shah

Dr Nicholas Goulden and Dr Chris Mitchell

John Smithies 01 December 2009
New UK childhood ALL trial: UK ALL 2011

Amount of grant: £750,000

Date of award: December 2009


Dr Nicholas Goulden, Great Ormond Street Hospital, London
Dr Chris Mitchell, John Radcliffe Hospital, Oxford

The latest national clinical trial for children with acute lymphoblastic leukaemia started in April 2011.

This replaces the previous trial, UK ALL 2003, which has revolutionised the way that children with acute lymphoblastic leukaemia (ALL) are treated.

Background – clinical trials and leukaemia treatment

Clinical trials help us to fin... Read More

Dr Paresh Vyas and Professor Irene Roberts

John Smithies 01 December 2009
Down's syndrome associated pre-leukaemia and leukaemia

Amount of grant: £922,319

Date of award: December 2009

Dr Paresh Vyas, Weatherall Institute for Molecular Medicine, Oxford and Professor Irene Roberts, Imperial College London

Children with Down's syndrome (DS) have a greatly increased risk of developing acute myeloid leukaemia (AML).

This project, which we are funding in collaboration with the Leukaemia Research Fund, is investigating the genetic changes which underlie this devastating association.

The defining feature of DS is three... Read More

Dr Malcolm Taylor, University of Manchester

John Smithies 01 December 2009
Systematic analysis of MHC-restricted antigen-specific T cell responses in children with leukaemia using T cell microarrays – a pilot validation study

Amount of grant: £314,697
Date of award: December 2009

Although childhood leukaemia is now very successfully treated – and in most cases cured – with chemotherapy, the ultimate goal is to prevent the disease altogether.

One possible approach to prevention builds on growing evidence of the role of the immune system in the development of leukaemia, by exploiting the body’s own immune defences to... Read More
Related Topics manchester, Dr Malcolm Taylor

Dr J Anderson and Dr M Pule, Institute for Child Health

John Smithies 08 December 2008
Assessment of anti-PAX5 immunotherapy for paediatric haematological and solid cancers

Amount of grant: £200,289

Date of award: December 2008


Dr John Anderson and Dr Martin Pule, Institute for Child Health, London



This ground-breaking research aims to help children who are failed by existing treatments.

Background

Most children with leukaemia are initially treated with high doses of chemotherapy – to kill the deadly leukaemia cells and enable blood cells to restore their vital functions.

Some children respond well to chemotherapy and n... Read More

Professor P Amrolia and Dr N Goulden, Institute of Child Health

John Smithies 01 December 2008
Immunotherapy after stem cell transplant in children with high-risk acute lymphoblastic leukaemia.

Amount of grant: £348,658

Date of award: December 2008

Professor Persis Amrolia and Dr Nicholas Goulden, Institute of Child Health, London


This ground-breaking research aims to help children who are failed by existing treatments.

Background

When a child is first diagnosed with leukaemia, doctors immediately start an aggressive chemotherapy regime to try to kill the leukaemia cells.

For some children this is enough. But others do not resp... Read More
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Tel: 020 7404 0808
Fax: 020 7404 3666

Registered Charity Number: 298405
Inaugurated by Diana, Princess of Wales

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