Research

Pioneering a new approach to stem cell transplant

Our funding is helping the research team develop a new way of using stem cell transplant to treat young people whose leukaemia has relapsed or failed to respond to chemotherapy.

Project Details

Immunotherapy with CD19 CAR redirected T cells for relapsed paediatric ALL (CARPALL)

Lead Researcher
Professor Persis Amrolia

Research Centre
UCL Institute of Child Health (via GOSH)

City & Institution Postcode
London WC1N 1EH

Start Date
19 January 2017

Project Duration
5 years

Grant Amount
£300,000

Overview

Stem cell transplant is often used to treat young people who are living with a certain type of leukaemia, in particular when the disease has relapsed or failed to respond to chemotherapy. However, it’s not always successful, and this pioneering project is developing a new immunotherapy approach to this form of treatment.

Thank you

This research project on stem cell transplant has been successfully completed. Your donations allow us to fund ground-breaking research that can improve treatments given to children with cancer. Thank you. Your help allows us to continue to find ways to drive up the chances of survival for children with cancer and reduce the toxic side effects that can affect the rest of their lives.

What difference will this project make?

The success of this project depends on the development of a new therapy based on the use of Chimeric Antigen Receptors, so is known as ‘CAR therapy’. In this exciting new approach, gene therapy is used to increase the ability of immune cells to recognise leukaemic cells. There is wide agreement that CAR therapy is the most promising development in the treatment of the leukaemia known as ALL. Our funding will enable the development of second generation CARs to benefit children in the UK, and will take them to clinical trial to test their safety and effectiveness. If this new technology is successful and the responses observed are durable, the new treatment may avoid the need for ALL-related stem cell transplant, reduce toxicity and improve the quality of life for young people living with this type of leukaemia.

About the Research Team

Professor Amrolia is Professor of Transplantation Immunology at UCL’s Institute of Child Health, and is Honorary Consultant in Bone Marrow Transplant at Great Ormond Street Hospital, which has the largest paediatric steam cell transplant programme in Europe. Professor Amrolia leads a highly collaborative team who are working on the development of therapies to improve anti-viral and anti-leukaemic responses after transplant, as well as more gentle methods of transplantation. He also has an established track record in the translation of basic scientific work into clinical practice for your people undergoing transplant.