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Patient Story – Darren

Darren was diagnosed with acute myeloid leukaemia (AML) when he was 11 years old.  Now in his 30’s, Darren tells us how this has affected his life:

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Refining our knowledge about the genetic causes of leukaemia

A large number of genetic mutations have been identified in childhood AML, with any one child having between 5 and 20 mutations. The role played by these mutations, alone and in combination, is not fully understood. This project will develop a model system that will facilitate the study of these mutations. Ultimately this will aid the development of more effective ...

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A new treatment approach in acute myeloid leukaemia

Acute myeloid leukaemia is the second most common form of childhood leukaemia, with 100 children diagnosed every year in the UK. Around a third of these young patients cannot be saved with existing treatments. Dr Mussai is taking forward a new approach to treatment that could offer new hope to children with this devastating disease.
We are grateful to the ...

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Understanding how the leukaemia gene EVI1 affects children with Fanconi anaemia

Fanconi anaemia (FA) is a rare, inherited blood disorder that leads to bone marrow failure. Children with FA have a greatly increased risk of developing leukaemia. Dr Meyer’s research focuses on a gene called EVI1 which is involved in the development of leukaemia in children both with and without FA. He wants to understand how the FA genetic defect works ...

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Understanding the increased risk of leukaemia for children with Down syndrome

Children with Down syndrome (DS) have a greatly increased risk of developing leukaemia. All babies and children with DS have abnormalities that affect how their bodies produce blood cells, but leukaemia develops in only a minority of them. This project, taking advantage of the unparalleled power of new technologies, aims to find out why.
We’re funding this project to find ...

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Study of the side-effects of the anti-leukaemia drug Asparaginase

One of the drugs used in the treatment of leukaemia is called Asparaginase, and helps in the treatment of many children. However, it can cause inflammation of the pancreas, and once children have developed this they can’t take it anymore. This project aims to find ways to protect pancreatic cells from the effects of this vital drug.
Our funding is ...

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