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Exploring retinoblastoma protein loss as an actionable target in paediatric bone and soft tissue sarcoma

The project investigates certain cancer of the soft tissue or bone (soft tissue and bone sarcomas) that have a mutation in the retinoblastoma tumour suppressor protein (RB1). Mutations in RB1 are found in nearly 30% of the childhood forms of these cancers. Although soft tissue or bone sarcomas are overall rare cancers, they represent the 2nd highest cause of cancer ...

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