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Identification of new genetic changes in rhabdomyosarcoma
Rhabdomyosarcoma (RMS) is a childhood cancer that develops in muscle, with 50 new cases every year in the UK. Older children in particular have a poor outlook and we need to improve our understanding of ...
A new treatment approach in acute myeloid leukaemia
Acute myeloid leukaemia is the second most common form of childhood leukaemia, with 100 children diagnosed every year in the UK. Around a third of these young patients cannot be saved with existing treatments. Dr ...
Assessment of physical function in survivors of childhood bone and soft tissue tumours
The treatment for bone and soft tissue tumours leaves many children disabled to some degree. We need to understand how these children manage after treatment in order that families get the necessary support to help ...
The role of the leukaemic stem cell in disease relapse
* this project is being funded in collaboration with Great Ormond Street Hospital Children’s Charity, with each charity contributing 50% of the total cost of £284,15 Acute lymphoblastic leukaemia is the most common form of ...
Advanced magnetic resonance imaging for improved diagnosis and prediction of treatment response in Wilms’ tumour patients
Wilms’ tumour is a cancer of the kidney, mostly affecting children under five. Overall survival rates are high, but there are different sub-types of Wilms’, and we can’t tell which type a child has without ...
Identifying markers of cancer stem cell derived tumour development and resistance in paediatric glioma
Professor Leach and his team are researching the cancer stem cells in paediatric glioblastoma. This brain tumour tends to resist treatment, and we need to find out why, so that life-saving new treatments can be developed ...