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Developing new immunotherapy techniques to target currently incurable brain tumours

Diffuse intrinsic Pontine Glioma (DIPG) and other gliomas in children remain some of the most difficult childhood cancers to treat, and new therapies are urgently needed to save the lives of children with these conditions. Survival rates are low, and there has been little improvement over the last 20 years.
But doctors have seen amazing results in trials using immunotherapy ...

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Does a harmless virus hold the key to delivering treatment for DIPG?

Paediatric diffuse intrinsic pontine glioma (DIPG) is a highly aggressive tumour, found at the base of the brain. Despite developments in cancer treatments – both in terms of new drugs and delivery methods – it remains very hard to treat, and the outlook for children with this cancer is poor.
In particular, the way that DIPG diffuses, or spreads, within ...

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How pGBM and DIPG tumours migrate and invade to help find clues to new treatments

Despite advances in our treatments for many types of cancer, the survival rate for children affected by tumours like paediatric glioblastoma (pGBM) and diffuse intrinsic pontine glioma (DIPG) remains low, and we urgently need new treatments.
One of the major challenges with these highly aggressive cancers is tumour invasion and, although we now understand a lot more about the biology ...

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