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Engineering immune cells for the optimal eradication of neuroblastoma

Neuroblastoma is one of the most common solid tumours to occur in children. It can be exceptionally difficult to treat and, despite intensive treatment, around one third of patients cannot currently be cured. In this project, Dr Gilham is harnessing the power of the immune system by engineering specific immune cells to destroy tumour cells. He will lay the essential ...

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Assessment of MIBG therapy in combination with cytotoxic drugs for neuroblastoma

Neuroblastoma, one of the most common childhood cancers, is often not diagnosed until it has spread to other parts of the body. At this stage it is very difficult to treat. A form of radiotherapy known as MIBG therapy has generated long-term remissions but cannot cure advanced disease. Professor Mairs is exploring the use of MIBG therapy in combination with ...

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Blood-based monitoring of treatment response in common childhood cancers.

In this project, the team is building on previous work profiling short pieces of genetic code, called microRNAs, in the blood of children being treated for cancer. They are now testing whether measurement of specific microRNAs in blood samples can be used to accurately assess response to treatment in common childhood cancers such as neuroblastoma, Wilms’ tumour and lymphoma.

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Combination treatments for neuroblastoma

Neuroblastoma is one of the most common childhood cancers. It has a high-risk form that is difficult to cure, despite intensive treatment.
This project aims to deliver a better understanding of ways to treat this devastating disease.  to cure, despite intensive treatment.

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Pre-clinical testing of a new treatment approach for rhabdomyosarcoma

Around 70 children are diagnosed with rhabdomyosarcoma every year in the UK. It is a cancer that is difficult to treat and remains a major cause of death from cancer in childhood, with little progress having been made in recent decades. The aim of this project is to take forward a new approach to the treatment of this disease.

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Implementing cardiac MRI to quantify heart damage in childhood cancer survivors.

Drugs used in the treatment of childhood cancer have a variety of adverse effects, including the risk of heart damage.
In this pilot project, Dr Hughes and colleagues are taking forward new techniques for accurately assessing cardiac damage in young patients and adult survivors.

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