About the research team Dr Julia Gerasimenko is one of the leading scientists in the UK working on acute pancreatitis. Together with Dr Oleg Gerasimenko they made the important discovery (Cell,1995) cited more than 331 times (Web of Science) about fundamental mechanism of calcium signalling. Oleg Gerasimenko is a member of the Editorial board of Pflügers Archiv–Eur JPhysiol. JG is a Faculty Member (F1000-Gastrointestinal-Physiology). Oleg Gerasimenko and Julia Gerasimenko have an excellent track record in researching AP and have made significant progress characterizing the pathological effects. The most important findings, published in Journal of Clinical Investigation (2018), PNAS (2009, 2011, 2013) and Current Biology 2012 clarified the molecular mechanisms responsible for AP initiation. Dr Sujith Samarasinghe is Consultant Paediatric Haematologist at Great Ormond Street Hospital in London. He is a key member of the national leukaemia toxicity group and has worked on defining toxicities for UKALL 2011, with a view to developing strategies to reduce their incidence. Recently, all three applicants published together studies exploring the molecular mechanism underlying AP induced as a side-effect of Asparaginase treatment of ALL and therefore have the ability to make significant progress in the proposed grant period.