About the research team This project will involve the laboratories of Dr Owen Williams and Dr Jasper de Boer, in the Cancer Section of the UCL Great Ormond Street Institute of Child Health, and those of Professor Olaf Heidenreich and Dr Deepali Pal, Northern Institute for Cancer Research, Newcastle University. The project will also benefit from collaboration with Dr Philip Ancliff and Dr Sujith Samarasinghe, senior consultant paediatric haematologists at GOSH. The laboratories of Dr Williams, Dr de Boer, Professor Heidenreich and Dr Pal have a track record in childhood leukaemia research. Over the last decade they have developed various models to investigate the molecular basis for leukaemia progression and susceptibilities to novel therapies. Together with Dr Ancliff, Dr Williams and Dr de Boer have also initiated a drug redeployment initiative in the Cancer theme of the joint institutions to identify and develop novel leukaemia therapies that can be ‘fast-tracked’ into the clinic. Dr Ancliff and Dr Samarasinghe will bring important clinical insights into this project and provide invaluable clinical experience to ensure the timely incorporation of novel therapies into clinical trials and practise.