Current treatments for childhood leukaemia achieve outstanding cure rates, but employ genotoxic compounds that can damage the genome of normal tissues. These treatments cause severe side effects during treatment and can also have substantial late effects such as reduced bone density, heart damage, fertility loss or development of new cancer. Novel, less genotoxic medicines are currently being explored but, when these drugs are used alone, the tumours often develop resistance, which leads to treatment failure.
Non-genotoxic combination treatments for paediatric acute leukaemias
Professor Olaf Heidenreich
4 July 2017