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TCR-transduced T cells for immunotherapy of paediatric high grade glioma
Diffuse intrinsic Pontine Glioma (DIPG) and other gliomas in children remain some of the most difficult childhood cancers to treat, and new therapies are urgently needed to save the lives of children with these conditions. ...
The developmental history of bilateral neuroblastoma
Neuroblastoma is one of the most common solid tumours affecting children, and remains very difficult to treat. Several studies have already used Next Generation Sequencing (NGS) to examine somatic alterations (the changes in DNA which ...
Investigation of a harmless prokaryotic virus for intravenous targeting delivery of therapeutic nucleic acids to DIPG
Paediatric diffuse intrinsic pontine glioma (DIPG) is a highly aggressive tumour, found at the base of the brain. Despite developments in cancer treatments – both in terms of new drugs and delivery methods – it ...
Mutational dynamics and their effect on chemoresistance and metastasis in a genetically engineered mouse model of relapsed neuroblastoma
Neuroblastoma is one of the most common solid tumours affecting children, and these days some forms of it are very treatable. But in high risk types, long-term survival rates are only 50%, particularly when a ...
The role of interclonal communication and the tumour microenvironment in driving paediatric GBM and DIPG migration and invasion
Despite advances in our treatments for many types of cancer, the survival rate for children affected by tumours like paediatric glioblastoma (pGBM) and diffuse intrinsic pontine glioma (DIPG) remains low, and we urgently need new ...
Children’s Brain Tumour Drug Delivery Consortium
Childhood brain tumours have remained difficult to treat, despite many advances in cancer treatments in recent years. One important reason for this is the blood-brain barrier (BBB). The BBB is intended to protect the brain, ...