2019 Research Grant Call for Research into Childhood Cancer Treatment and Survival.
Children with Cancer UK invited proposals for research projects and clinical PhD studentships that addressed improved treatment for and survival from childhood and young person cancer and into improved quality of ongoing life.
The deadline for proposals passed on 5th April 2019. We received a total of 50 preliminary proposals for our 2019 Research Grant Call for Research into Childhood Cancer Treatment and Survival.
Following initial triage by our Scientific Advisory Panel, 31 applicants were invited to submit full proposals, which were assessed by external peer review. Our Scientific Advisory Panel for this grant call met on 26th & 27th February 2020 to review these applications. Present at the meeting were Dr Chris Halsey, Dr Lynley Marshall, Dr Nick Goulden and Professor Roderick Skinner, Chaired by Dr Owen Williams.
|Principal investigator||Host institution||Grant title||Total|
|Professor Chris Jones||Institute of Cancer Research||Evolutionary dynamics of MEK inhibitor sensitivity and resistance in diffuse midline glioma||£349,393|
|Professor Kathy Pritchard-Jones||UCL Great Ormond Street Institute of Child Health||International benchmarking of childhood cancer survival by stage||£349,746.50|
|Dr Marc Mansour||UCL Cancer Institute||A novel immunotherapy target in T-cell acute lymphoblastic leukaemia (T-ALL)||£349,746.50|
|Dr Claire Clarkin||University of Southampton||Developing 3-dimensional multicellular models of osteosarcoma||£49,984|
|Professor Mike Hawkins||University of Birmingham||Establish a comprehensive surveillance system for adverse health outcomes in British survivors of childhood, teenage and young adult cancer||£349,982.37|
|Professor Veronica Kinsler||UCL Great Ormond Street Institute of Child Health||Identification of new therapies for melanoma in congenital melanocytic naevi – a universally fatal paediatric tumour||£249,755.76|
|Professor Anthony Chalmers||University of Glasgow||Increasing the susceptibility of neuroblastoma cells to radiotherapy by targeting glycolysis and lipogenesis||£249,774|
|Dr Sam Behjati||Wellcome Sanger Institute||Developmental states of localised and metastatic osteosarcoma cells – a knowledge bank for novel biomarkers and therapeutic approaches||£349,418.96|
|Professor Julie Irving||Newcastle University||Optimising the use of repurposed drugs to improve the treatment of children with ALL||£213,259|
|Professor Steve Clifford||Newcastle University||SMILE: An International network for Medulloblastoma Survivorship and Late-Effects||£348,783.27|
|Professor John Anderson||UCL Great Ormond Street Institute of Child Health||Pilot to develop CRISPR library screen for enhanced function of G-D-T cells in paediatric solid cancers||£49,929.66|
|Dr Macarena Oporto Espuelas||UCL Great Ormond Street Institute of Child Health||Identification of novel surface antigen targets for CAR T cell strategies in paediatric Acute Myeloid Leukaemia stem cells||£220,000|
|Dr Defne Saatci||UCL Great Ormond Street Institute of Child Health||Investigating Late Effects of Surviving Childhood Cancer||£216,963.40|
|Dr John Murphy||University of Westminster||A pilot Investigation of the ZFP36L1 protein as a candidate therapeutic target in osteosarcoma cells||£14,013|
|Dr Raoul Reulen||University of Birmingham||Pilot study to investigate self-reported health behaviours in survivors of teenage and young adult cancer||£5,000|