2019 Research Grant Call

2019 Research Grant Call for Research into Childhood Cancer Treatment and Survival.

15 projects were awarded grants totalling £3,265,328

Children with Cancer UK invited proposals for research projects and clinical PhD studentships that addressed improved treatment for and survival from childhood and young person cancer and into improved quality of ongoing life.

The deadline for proposals passed on 5th April 2019. We received a total of 50 preliminary proposals for our 2019 Research Grant Call for Research into Childhood Cancer Treatment and Survival.

Following initial triage by our Scientific Advisory Panel, 31 applicants were invited to submit full proposals, which were assessed by external peer review. Our Scientific Advisory Panel for this grant call met on 26th & 27th February 2020 to review these applications. Present at the meeting were Dr Chris Halsey, Dr Lynley Marshall, Dr Nick Goulden and Professor Roderick Skinner, Chaired by Dr Owen Williams.

Important Dates & Times

    Awards made

  • 29/11/2019

The following projects were awarded grants, totalling £3,265,328


Principal investigator

Professor Chris Jones

Host institution

Institute of Cancer Research

Grant title

Evolutionary dynamics of MEK inhibitor sensitivity and resistance in diffuse midline glioma



Professor Kathy Pritchard-Jones 

UCL Great Ormond Street Institute of Child Health


International benchmarking of childhood cancer survival by stage£349,746.50
Dr Marc MansourUCL Cancer Institute 

A novel immunotherapy target in T-cell acute lymphoblastic leukaemia (T-ALL)

Dr Claire ClarkinUniversity of SouthamptonDeveloping 3-dimensional multicellular models of osteosarcoma£49,984
Professor Mike HawkinsUniversity of Birmingham 

Establish a comprehensive surveillance system for adverse health outcomes in British survivors of childhood, teenage and young adult cancer


Professor Veronica Kinsler 

UCL Great Ormond Street Institute of Child Health



Identification of new therapies for melanoma in congenital melanocytic naevi – a universally fatal paediatric tumour

Professor Anthony ChalmersUniversity of Glasgow 

Increasing the susceptibility of neuroblastoma cells to radiotherapy by targeting glycolysis and lipogenesis

Dr Sam BehjatiWellcome Sanger Institute 

Developmental states of localised and metastatic osteosarcoma cells – a knowledge bank for novel biomarkers and therapeutic approaches

Professor Julie IrvingNewcastle University 

Optimising the use of repurposed drugs to improve the treatment of children with ALL

Professor Steve CliffordNewcastle University 

SMILE:  An International network for Medulloblastoma Survivorship and Late-Effects

Professor John Anderson 

UCL Great Ormond Street Institute of Child Health



Pilot to develop CRISPR library screen for enhanced function of G-D-T cells in paediatric solid cancers

Dr Macarena Oporto Espuelas 

UCL Great Ormond Street Institute of Child Health



Identification of novel surface antigen targets for CAR T cell strategies in paediatric Acute Myeloid Leukaemia stem cells

Dr Defne Saatci 

UCL Great Ormond Street Institute of Child Health


Investigating Late Effects of Surviving Childhood Cancer£216,963.40
Dr John Murphy 

University of Westminster



A pilot Investigation of the ZFP36L1 protein as a candidate therapeutic target in osteosarcoma cells

Dr Raoul ReulenUniversity of Birmingham 

Pilot study to investigate self-reported health behaviours in survivors of teenage and young adult cancer



Children with Cancer UK is a member of the Association of Medical Research Charities (AMRC), which sets minimum standards of good practice to which member charities must adhere in their grant-making, including policies on peer review.

We are also a member of the National Cancer Research Institute (NCRI), a partnership of UK cancer funders.

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