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  • acute Lymphoblastic Leukaemia |
  • Immunotherapy projects

Combinatorial targeting of Anaplastic Lymphoma Kinase (ALK) for neuroblastoma immunotherapy

Professor Persis Amrolia, UCL Institute of Child Health, London

Stem cell transplant is used as a treatment of last resort in young patients with acute lymphoblastic leukaemia (ALL) whose disease has failed to respond to or relapsed after chemotherapy. Only half of patients undergoing ...

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  • Brain and Spinal Tumours

Our Brain Tumour Initiative

Eight brain tumour research projects, Nottingham, Birmingham, Edinburgh and London

Brain tumours account for a quarter of childhood cancer diagnoses and more than a third of childhood cancer deaths.
Childhood brain tumours are treated aggressively to give each child the very best chance of survival. ...

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  • Precision Medicine

Research into a comprehensive and structured approach to genetic testing to match children with cancer to specific targeted treatments

Professor Louis Chesler, The Institute of Cancer Research

We’re proud to announce £1.5m Precision Medicine funding for targeted, less toxic cancer treatments.
Precision Medicine is an exciting new way to deliver cancer treatment to children. It takes into account individual variations in genes, ...

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  • Brain and Spinal Tumours

Identification of new genetic changes in rhabdomyosarcoma

Professor Jill Birch, University of Manchester

Rhabdomyosarcoma (RMS) is a childhood cancer that develops in muscle, with 50 new cases every year in the UK. Older children in particular have a poor outlook and we need to improve our understanding of ...

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  • Brain and Spinal Tumours

Assessment of physical function in survivors of childhood bone and soft tissue tumours

Mr Craig Gerrand, Freeman Hospital

The treatment for bone and soft tissue tumours leaves many children disabled to some degree. We need to understand how these children manage after treatment in order that families get the necessary support to help ...

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  • acute Lymphoblastic Leukaemia

The role of the leukaemic stem cell in disease relapse

Professor Tariq Enver, UCL Cancer Institute

* this project is being funded in collaboration with Great Ormond Street Hospital Children’s Charity, with each charity contributing 50% of the total cost of £284,15
Acute lymphoblastic leukaemia is the most common form of ...

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Current research

One of the greatest medical success stories of the last century is the amazing growth in the survival from childhood cancer. Fifty years ago, only a quarter of children diagnosed with cancer survived. Today, more than 80 per cent of young patients can be successfully treated.

However, cancer still claims the lives of around 250 children every year in the UK. And unfortunately the children who survive may be left with serious health and developmental problems as a result of the intensive treatments used to save their young lives.

Through our investment in research, we are taking forward our understanding of childhood cancer, to give new insights into ways of treating young patients with even the most difficult forms of cancer. We hope to drive up the survival rate still further whilst reducing the risk of harm.