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Developing new immunotherapy techniques to target currently incurable brain tumours

Diffuse intrinsic Pontine Glioma (DIPG) and other gliomas in children remain some of the most difficult childhood cancers to treat, and new therapies are urgently needed to save the lives of children with these conditions. Survival rates are low, and there has been little improvement over the last 20 years.
But doctors have seen amazing results in trials using immunotherapy ...

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Immunotherapy for relapsed paediatric acute lymphoblastic leukaemia

Stem cell transplant is used as a treatment of last resort in young patients with acute lymphoblastic leukaemia (ALL) whose disease has failed to respond to or relapsed after chemotherapy. Only half of patients undergoing transplant are cured long-term, and disease relapse is the major cause of treatment failure. Professor Amrolia is pioneering the development of a new immunotherapy approach ...

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Reducing toxicity in treatment for children with high-risk neuroblastoma

Neuroblastoma is one of the most common childhood tumours, and in its high-risk form is one of the most difficult childhood cancers to cure, despite intensive therapy. This important project is researching a new immunotherapy approach to develop more effective and less toxic treatments to give more children a chance of survival.
New approaches to treating high-risk neuroblastoma in children ...

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Focusing on immunotherapy to target cancer cells without damaging healthy cells

Developing new treatments for childhood cancers can be difficult because we need to find way to deal with cancer cells without damaging healthy cells. The ground-breaking field of immunotherapy is playing an increasingly important part in treatment, and Dr Kathleen’s remarkable work will focus on making antibodies that attach themselves to a protein that helps cancer cells grow.
This clinical ...

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Studying the relationship between HIV, infection and childhood cancer

Infections are known to cause various types of cancer, some of which can be prevented either by treating the infection or vaccinating against it. The HIV virus is particularly adept at damaging the body’s ability to fight infection, increasing its susceptibility to infection-related cancers. This pioneering project is focusing on the relationship between HIV and childhood cancer.
Our funding is ...

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Developing immunotherapy for childhood sarcomas

Some childhood cancers don’t respond well to chemotherapy, but there is hope in the form of immunotherapy. Doctors have already achieved success using immunotherapy techniques to treat children with leukaemia and neuroblastoma. Now Professor John and his team aim to extend these techniques to treating childhood sarcomas.
For childhood cancers that don’t respond well to chemotherapy, immunotherapy offers new hope. Children ...

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