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Stem cell transplant is used as a treatment of last resort in young patients with acute lymphoblastic leukaemia (ALL) whose disease has failed to respond to or relapsed after chemotherapy. Only half of patients undergoing transplant are cured long-term, and disease relapse is the major cause of treatment failure. Professor Amrolia is pioneering the development of a new immunotherapy approach ...
Neuroblastoma is one of the most common childhood tumours, and in its high-risk form is one of the most difficult childhood cancers to cure, despite intensive therapy. This important project is researching a new immunotherapy approach to develop more effective and less toxic treatments to give more children a chance of survival. New approaches to treating high-risk neuroblastoma in children ...
Developing new treatments for childhood cancers can be difficult because we need to find way to deal with cancer cells without damaging healthy cells. The ground-breaking field of immunotherapy is playing an increasingly important part in treatment, and Dr Kathleen’s remarkable work will focus on making antibodies that attach themselves to a protein that helps cancer cells grow. This clinical ...
Infections are known to cause various types of cancer, some of which can be prevented either by treating the infection or vaccinating against it. The HIV virus is particularly adept at damaging the body’s ability to fight infection, increasing its susceptibility to infection-related cancers. This pioneering project is focusing on the relationship between HIV and childhood cancer. Our funding is ...
Some childhood cancers don’t respond well to chemotherapy, but there is hope in the form of immunotherapy. Doctors have already achieved success using immunotherapy techniques to treat children with leukaemia and neuroblastoma. Now Professor John and his team aim to extend these techniques to treating childhood sarcomas. For childhood cancers that don’t respond well to chemotherapy, immunotherapy offers new hope. Children ...
Immunotherapy is an important new approach in the treatment of cancer. In this project, Professor Waseem is pioneering an approach using immune cells taken from donated umbilical cord blood instead of a child’s own cells, to help treat children who don’t have enough of their own immune cells after chemotherapy.