In this project, the team is building on previous work profiling short pieces of genetic code, called microRNAs, in the blood of children being treated for cancer. They are now testing whether measurement of specific microRNAs in blood samples can be used to accurately assess response to treatment in common childhood cancers such as neuroblastoma, Wilms’ tumour and lymphoma.
Wilms’ tumour is a cancer of the kidney, mostly affecting children under five. Overall survival rates are high, but there are different sub-types of Wilms’, and we can’t tell which type a child has without surgery. This project is developing advanced MRI techniques to help us diagnose accurately before operating and provide earlier, targeted treatment.
We’re funding an important project ...
Although many children with Wilms’ tumour are successfully treated with a combination of surgery and chemotherapy, some are still dying from this disease. There is an urgent need to know more about why it develops, so the team is investigating the very basic biology of these tumours to help predict disease outcome and enable doctors to tailor treatments to individual ...Read more