Children with the genetic disorder Noonan syndrome (NS) have a high risk of developing leukaemia. This project is examining differences in the blood stem cells of NS patients who did or did not develop leukaemia. This will then increase our understanding of what causes blood to become leukaemic, and find targets for treatment.
Our funding is focused on examining why certain children with the rare genetic disorder Noonan syndrome develop leukaemia while others do not, and will result in the development of new treatments.
This research project on the rare genetic disorder Noonan syndrome has been successfully completed. Your donations allow us to fund ground-breaking research that can improve treatments given to children with cancer. Thank you. Your help allows us to continue to find ways to drive up the chances of survival for children with cancer and reduce the toxic side effects that can affect the rest of their lives.
Characterising abnormal signalling pathway activation by PTPN11 mutations in Noonan syndrome and juvenile myelomonocytic leukaemia
Professor Anthony Whetton
University of Manchester
Manchester M20 3LJ
1 January 2015