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Molecular evolution of Wilms Tumour
Although many children with Wilms’ tumour are successfully treated with a combination of surgery and chemotherapy, some are still dying from this disease. There is an urgent need to know more about why it develops, ...
The role of histone H4K20 methylation in paediatric glioblastoma and DIPG
This project is looking paediatric glioblastoma (pGBM) and diffuse intrinsic pontine glioma (DIPG), two brain tumours that affect children, and are currently incurable. To stop children dying from them, we need to learn more about ...
Genome editing of human neural stem cells using nuclease-assisted gene targeting: a tool to uncover the function of H3F3A mutations in paediatric glioma.
International collaboration is often the best way to approach difficult research problems, and this is how we’re searching for new ways to treat the brain tumour called glioblastoma. Teams from the UK, Canada and Sweden ...
Global RNA profiles of trisomic, pre-leukaemic and leukaemic haemopoietic cells in Down syndrome
Children with Down syndrome (DS) have a greatly increased risk of developing leukaemia. All babies and children with DS have abnormalities that affect how their bodies produce blood cells, but leukaemia develops in only a ...
Dissecting the causative and collaborating roles of candidate genetic mutations in the pathogenesis of childhood ALL
The cure rates for leukaemia have increased over the past 20 years, but we still have a lot of work to do. This project will increase our understanding of the genetic changes underlying one form ...
Developing zebrafish models of inherited AML to interrogate secondary driver events
The second most common form of childhood leukaemia is known as AML, and a large number of genetic mutations have been identified in it. The role played by these mutations is not fully understood yet, ...