Causes

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Learning about Wilms’ tumour to find new treatments

Molecular evolution of Wilms Tumour

Professor Kathy Pritchard-Jones, Institute of Child Health, University College London

Understanding treatment-resistance and disease-spread in childhood gliomas

The role of histone H4K20 methylation in paediatric glioblastoma and DIPG

Professor Chris Jones, Institute of Cancer Research

Understanding the genetics of paediatric glioblastoma

Genome editing of human neural stem cells using nuclease-assisted gene targeting: a tool to uncover the function of H3F3A mutations in paediatric glioma.

Dr Steven Pollard, The University of Edinburgh

Understanding the increased risk of leukaemia for children with Down syndrome

Global RNA profiles of trisomic, pre-leukaemic and leukaemic haemopoietic cells in Down syndrome

Professor Irene Roberts, University of Oxford

Understanding the complex genetic changes that lead to childhood leukaemia

Dissecting the causative and collaborating roles of candidate genetic mutations in the pathogenesis of childhood ALL

Professor Tariq Enver, UCL Cancer Institute

Understanding the role genetic mutations play in acute myeloid leukaemia

Developing zebrafish models of inherited AML to interrogate secondary driver events

Dr Elspeth Payne, University College London

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