Molecular evolution of Wilms Tumour
Professor Kathy Pritchard-Jones, Institute of Child Health, University College LondonAlthough many children with Wilms’ tumour are successfully treated with a combination of surgery and chemotherapy, some are still dying from this disease. There is an urgent need to know more about why it develops, ...
Read moreThe role of histone H4K20 methylation in paediatric glioblastoma and DIPG
Professor Chris Jones, Institute of Cancer ResearchThis project is looking paediatric glioblastoma (pGBM) and diffuse intrinsic pontine glioma (DIPG), two brain tumours that affect children, and are currently incurable. To stop children dying from them, we need to learn more about ...
Read moreGenome editing of human neural stem cells using nuclease-assisted gene targeting: a tool to uncover the function of H3F3A mutations in paediatric glioma.
Dr Steven Pollard, The University of EdinburghInternational collaboration is often the best way to approach difficult research problems, and this is how we’re searching for new ways to treat the brain tumour called glioblastoma. Teams from the UK, Canada and Sweden ...
Read moreGlobal RNA profiles of trisomic, pre-leukaemic and leukaemic haemopoietic cells in Down syndrome
Professor Irene Roberts, University of OxfordChildren with Down syndrome (DS) have a greatly increased risk of developing leukaemia. All babies and children with DS have abnormalities that affect how their bodies produce blood cells, but leukaemia develops in only a ...
Read moreDissecting the causative and collaborating roles of candidate genetic mutations in the pathogenesis of childhood ALL
Professor Tariq Enver, UCL Cancer InstituteThe cure rates for leukaemia have increased over the past 20 years, but we still have a lot of work to do. This project will increase our understanding of the genetic changes underlying one form ...
Read moreDeveloping zebrafish models of inherited AML to interrogate secondary driver events
Dr Elspeth Payne, University College LondonThe second most common form of childhood leukaemia is known as AML, and a large number of genetic mutations have been identified in it. The role played by these mutations is not fully understood yet, ...
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