Combinatorial targeting of Anaplastic Lymphoma Kinase (ALK) for neuroblastoma immunotherapy
Professor Persis Amrolia, UCL Institute of Child Health, LondonStem cell transplant is used as a treatment of last resort in young patients with acute lymphoblastic leukaemia (ALL) whose disease has failed to respond to or relapsed after chemotherapy. Only half of patients undergoing ...
Read moreCombinatorial targeting of Anaplastic Lymphoma Kinase (ALK) for neuroblastoma immunotherapy
Professor John Anderson, Institute of Child Health, University College LondonNeuroblastoma is one of the most common childhood tumours, and in its high-risk form is one of the most difficult childhood cancers to cure, despite intensive therapy. This important project is researching a new immunotherapy ...
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ALL 2011
Dr Pamela Kearns, University of BirminghamThis national clinical trial for children with the form of leukaemia known as acute lymphoblastic leukaemia (ALL) is building on the success of a previous trial. This pioneered a ground-breaking technique that placed children in ...
Read morePathophysiology of asparaginase associated pancreatitis
Dr Oleg Gerasimenko, Cardiff UniversityOne of the drugs used in the treatment of leukaemia is called Asparaginase, and helps in the treatment of many children. However, it can cause inflammation of the pancreas, and once children have developed this ...
Read moreSenior lecturer in translational paediatric haemopoiesis
Professor Tessa Holyoake, University of GlasgowWe’re funding a senior researcher to lead a new childhood leukaemia research team at the Paul O’Gorman Leukaemia Research Centre in Glasgow. The team will research the causes, mechanisms and treatment of childhood leukaemia, particularly ...
Read moreOptimisation of the use of L-Asparaginase and Dexamethasone in Childhood Acute Lymphoblastic Leukaemia
Professor Vaskar Saha, University of ManchesterWhen children living with cancer are treated, their bodies metabolise – or break down – the drugs used in many different ways. The team aim to tailor therapies to individual children based on their drug ...
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