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  • acute Lymphoblastic Leukaemia |
  • Immunotherapy projects

Combinatorial targeting of Anaplastic Lymphoma Kinase (ALK) for neuroblastoma immunotherapy

Professor Persis Amrolia, UCL Institute of Child Health, London

Stem cell transplant is used as a treatment of last resort in young patients with acute lymphoblastic leukaemia (ALL) whose disease has failed to respond to or relapsed after chemotherapy. Only half of patients undergoing ...

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  • Immunotherapy projects |
  • Neuroblastoma

Combinatorial targeting of Anaplastic Lymphoma Kinase (ALK) for neuroblastoma immunotherapy

Professor John Anderson, Institute of Child Health, University College London

Neuroblastoma is one of the most common childhood tumours, and in its high-risk form is one of the most difficult childhood cancers to cure, despite intensive therapy. This important project is researching a new immunotherapy ...

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  • acute Lymphoblastic Leukaemia

ALL 2011

Dr Pamela Kearns, University of Birmingham

This national clinical trial for children with the form of leukaemia known as acute lymphoblastic leukaemia (ALL) is building on the success of a previous trial. This pioneered a ground-breaking technique that placed children in ...

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  • acute Lymphoblastic Leukaemia |
  • Acute Myeloid Leukaemia

Pathophysiology of asparaginase associated pancreatitis

Dr Oleg Gerasimenko, Cardiff University

One of the drugs used in the treatment of leukaemia is called Asparaginase, and helps in the treatment of many children. However, it can cause inflammation of the pancreas, and once children have developed this ...

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  • Acute Myeloid Leukaemia

Senior lecturer in translational paediatric haemopoiesis

Professor Tessa Holyoake, University of Glasgow

We’re funding a senior researcher to lead a new childhood leukaemia team at the Paul O’Gorman Leukaemia Research Centre in Glasgow. The team will research the causes, mechanisms and treatment of childhood leukaemia, particularly looking ...

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  • acute Lymphoblastic Leukaemia

Optimisation of the use of L-Asparaginase and Dexamethasone in Childhood Acute Lymphoblastic Leukaemia

Professor Vaskar Saha, University of Manchester

When children living with cancer are treated, their bodies metabolise – or break down – the drugs used in many different ways. The team aim to tailor therapies to individual children based on their drug ...

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