Newsletter Signup x

Diagnosing childhood medulloblastomas by improved MRI scans

The most common childhood brain tumours are called medulloblastomas. They are divided into different types, and because each responds differently to treatment, rapid diagnosis is essential. This project is focused on developing a new tool to allow quick diagnosis that can then be used when it comes to making decisions about treatment.

Our funding is helping doctors who work with children living with one of the most common form of brain tumours to develop a new diagnostic tool that uses MRI scanning techniques instead of surgery.

scientist researching treatment improvements for acute lymphoblastic leukaemia

Project Details

  • Project Title

    Non invasive identification of medulloblastoma genetic subtypes using metabolite profiles and imaging features

  • Lead Researcher

    Professor Andrew Peet

  • Research Centre

    Institute of Child Health, University of Birmingham

  • City & Institution Postcode

    Birmingham B4 6NH

  • Start Date

    1 June 2015

  • Duration

    4 years and 4 months

  • Grant Amount



Research Stories - Paediatric brain tumour initiative

Our brain tumour initiative

In 2014, in response to the apparent dearth of funding going into paediatric brain tumour research, we ring-fenced ...

Read more
Mother and daughter

Brain and Spinal Tumours

Information about brain tumours

Every year, there are around 400 new cases of cancer of the spine or brain, these include: medulloblastoma, ...

Read more
Blake in hospital

Patient story – Blake

Meet Blake - one of our hero patient stories

Blake was three years old when he was diagnosed with medulloblastoma – a brain tumour. His mum, Llian, tells ...

Read more


The most common malignant brain tumours in children are called medulloblastomas, and the four main sub-types have their own genetic make-up. Diagnosis is currently carried out by performing surgery to obtain a tumour sample, which is then sent to a laboratory for analysis.

In this project, Professor Peet and his colleagues will develop a new diagnostic tool that uses special MRI scanning techniques instead of surgery, and the team will also design a test that can distinguish between the chemical profiles of the different tumours. To do this, they will build up a ‘reference library’ containing up to 160 samples during the course of the project.

What difference will this project make?

The ultimate aim of this project is to develop non-invasive methods for diagnosing the sub-types of a common type of brain tumour. This will allow medical teams to plan treatment at the time the child is first referred, rather than waiting days or even weeks for surgery and the subsequent processing of samples.

This earlier diagnosis should help to improve outcomes by allowing more informed initial treatment decisions and earlier treatment planning. It will also aid discussions with the child and family in the crucial early stages of their admission to hospital.

Early diagnosis of the sub-types may also help to avoid unnecessary surgery and some of the associated complications, some of which can have serious implications for a young person’s quality of life in the future.

The insights that this project will offer into the metabolism of tumours may allow radically new treatment approaches to be taken, and in the future, accurate non-invasive diagnosis may avoid surgery altogether.


About the Research Team

Andrew Peet is Professor of Paediatric Oncology at the University of Birmingham and Honorary Consultant at Birmingham Children’s Hospital. He leads the Brain Tumour Research Group at the University of Birmingham, which is developing imaging for the diagnosis and management of childhood brain tumours.

This project builds on collaborations between Birmingham’s Brain Tumour Research Group, the Children’s Brain Tumour Research Centre in Nottingham, and the Medulloblastoma Biology Group at Newcastle University. These form an essential link between imaging and tumour biology, and the team is well placed to take methods developed by the project and translate them into routine clinical practice.

Newsletter icon

Know someone who might be interested in this article?

Email this page to a friend!

Using international teamwork to treat brain tumours

Related research- Professor Richard Grundy

One of the most challenging brain tumours to treat is called ependymoma. A unique partnership called BIOMECA is ...

Read more
Martinez Barbera

New tools to improve treatment and care in paediatric craniopharyngioma

Related research - Dr Juan Pedro Martinez-Barbera

Children affected by the brain tumour known as ACP can have a positive future, but in many cases ...

Read more
Two cyclists waving at the camera at the Prudential ride London 100

Choose one of our amazing fundraising events today!

Fundraise for us today!
Read more